Beat the Odds in CNS Drug Development
Central Nervous System (CNS) drug development faces a high failure rate — 85% of Phase II–III studies fail due to disease complexity, high placebo response, and subjective assessments. Cytel helps address these challenges with advanced statistical methodologies, adaptive trial designs, and AI-driven analytics, helping you de-risk your trial and increase the probability of success.
CNS Drug Development Is Expensive — Avoid Costly Failures
Cytel is at the forefront of CNS drug development. Our solutions and proven expertise can guide you through the unique challenges faced within CNS drug development:
- Unreliable Preclinical Models — Many animal models fail to replicate human CNS diseases, limiting their predictive value.
- Difficult Clinical Measurements — Difficult clinical measurements lead to a reliance on surrogate endpoints.
- Patient Adherence Issues — Cognitive and physical impairments make it harder for patients to follow treatment regimens.
- Subjective and Variable Assessments — Many CNS measures lack standardization, are prone to bias, and reduce data reliability.
- Need for Early Validation — Strong Proof of Mechanism (PoM) and Proof of Concept (PoC) are essential to de-risk late-stage failures.
Stack the Odds in Your Favor: Solutions That Increase Probability of Success
Traditional approaches to drug development don’t always meet the needs of those who study CNS disorders. Our team can help you assemble the best methods available to fully unlock the power and promise of new therapies. Our toolkit includes:
- Adaptive and innovative trial designs
- PBPK modeling and simulation for early-stage decisions
- RWE and RWD solutions
- East Horizon™ platform: Industry-leading software for simulation-based design, with innovative AI-driven features and advanced with R integration for advanced capabilities
- Inclusion of patient-reported outcomes
- Data management services
- Independent data monitoring committees (DMC)
300+
Projects supported in neurology and CNS over the past 5 years.
17%
Of all Cytel projects are in CNS, second only to oncology.
5
Treatment types supported: drug, biologic, device, immunotherapy, and gene therapy.
Claim your free 30-minute strategy session
Book a free, no-obligation strategy session with a Cytel expert to get advice on how to improve your drug’s probability of success and plot a clearer route to market.