Using Machine Learning to Identify Sub-Groups of Patients that Benefit from Treatment
How can machine learning (ML) methods help uncover populations in which the intervention is most effective?
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In a large pharmaceutical client’s double-blind study in severe infectious disease, the patients failed to meet the primary endpoint. A subset of the patients showed benefit with the treatment, but a variety of simple sub-group analyses were unable to identify which patients could benefit from active treatment versus standard of care.
Cytel used machine learning (ML) to help the client identify a subset of patients that could potentially benefit from their treatment.