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This ebook is an effort to explain common strategies for the construction of SCAs, and to give a high-level overview of how statisticians think through challenges encountered during trial design. Awareness of these varying practices might enable the non-specialist to determine under what circumstances a placebo-controlled RCT is most appropriate and under what conditions to use single arm trial combined with an SCA. The goal is to create a framework to help readers explore various uses of data and how these approaches can help in achieving the goals of clinical development programs.