Industry-Leading Clinical Trial Design Software

Cytel’s East Horizon™ platform is an integrated clinical trial design platform that combines trusted statistical design methods with scalable simulation capabilities and the flexibility of open-source R integration. The platform supports a broad range of trial design and simulation workflows, enabling users to design, evaluate, and optimize clinical trials. The East Horizon platform integrates original East methods in addition to newly developed and more
innovative methods addressing both early-phase and late-phase designs, empowering users to design and execute an even wider range of clinical trials across all development stages with precision and efficiency.

Cytel’s trial design software portfolio is centered around the East Horizon™ platform, which brings together decades of innovation in clinical trial design into a single integrated environment. The platform includes modules for dose escalation, dose finding, fixed sample, group sequential, multiplicity, and adaptive trial designs, with built-in simulation capabilities and R integration. Cytel also offers the Xact® software suite, including StatXact® and LogXact®, which provides exact statistical methods for small samples, sparse data, and other complex analyses commonly encountered in clinical research.

Yes. Cytel’s East® software has long been recognized for supporting adaptive clinical trial design, and these capabilities are now available within the East Horizon™ platform. Users can design and evaluate a broad range of adaptive studies, including sample size re-estimation, population enrichment, group sequential designs, dose escalation, Phase II/III seamless designs, and other adaptive trial approaches. Combined with simulation-based study approaches, these capabilities help teams evaluate design alternatives, support interim decision-making, and optimize trial designs while maintaining statistical rigor.

Yes. Cytel’s software supports clinical trial protocol design and optimization. Cytel’s East Horizon™ platform helps biostatisticians design and optimize clinical trial protocols by enabling them to evaluate multiple study design options before a trial begins. Through advanced trial simulation, Frequentist and Bayesian design methods, sample size optimization, and adaptive design capabilities, users can compare design alternatives, assess operating characteristics, and identify approaches that balance study duration, cost, and probability of success. This simulation-based approach helps teams make more informed protocol design decisions with greater confidence.

Yes. The East Horizon™ platform includes an AI-powered R Coding Assistant that enables users to generate R code from natural language prompts. The assistant is purpose-built for clinical trial design and biostatistics, generating code that integrates directly with the platform’s simulation engine. This enables users to extend the platform’s native capabilities with custom statistical methods and simulation models.